Research article
The crystal structure of superoxide dismutase from Plasmodium falciparum
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* Corresponding author: James A Brannigan jab@ysbl.york.ac.uk
1 Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5YW, UK
2 Molecular Parasitology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
3 Bioinformatics Institute, 30 Biopolis St., Singapore 138671, Singapore
BMC Structural Biology 2006, 6:20 doi:10.1186/1472-6807-6-20
Published: 4 October 2006Additional files
Additional File 1:
Model of the P. falciparum mitochondrially targeted FeSOD2. Data file PfSOD2_model.pdb.
Format: PDB Size: 256KB Download file
Additional File 2:
Sequence alignment of Plasmodia FeSOD sequences. FeSOD is one the most highly conserved proteins across different Plasmodium species [40]. Identical residues are highlighted with a red background and similar residues are boxed. PfFeSOD secondary structure elements are superposed. Codes: Pf, P. falciparum; Pr, P. reichenowi; Po, P. ovalae; Pm, P. malariae; Pv, P. vivax; Pk, P. knowlesi; Py, P. yeolii; Pb, P. berghei; Pc, P. chabaudi; Pg, P. gallinaceum. The figure was made using ESPript [38].
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Additional File 3:
Gene model of PfFeSOD2. A region of DNA sequence from P. falciparum chromosome 6 is shown, with predicted introns highlighted in yellow, and the protein product of the exon sequences in red.
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Additional File 4:
Sequence alignment of predicted PfFeSOD2 proteins from Plasmodium species. Identical residues are highlighted with a red background and similar residues are boxed. PfFeSOD2 predicted secondary structure elements are superposed and exon boundaries are marked with a triangle. Note that the first two exons coincide with the putative signal sequence and transit peptide. Sequence data were gleaned from PlasmoDB [14]. Although not shown, the incomplete sequence data from P. chabaudi (missing region around exons 4 & 5) and P. gallinaceum (missing region encompassing 6 & 7) also show the same conserved pattern of putative intron boundaries. Codes: Pf, P. falciparum; Pr, P. reichenowi; Pv, P. vivax; Pk, P. knowlesi; Pb, P. berghei; Py, P. yeolii.
Format: PPT Size: 1.1MB Download file
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