Figure 1.

The domain structure of the RBBP6 family of proteins. RBBP6 homologues containing a DWNN domain, a zinc knuckle and a RING finger are found in all complete eukaryotic genomes analysed to date, including the single celled parasite E. cuniculi, in which it is very much reduced in size. In vertebrates and insects the protein includes a long C-terminal extension containing p53 and Rb-interaction domains in human and mouse. A short form consisting of the DWNN domain and a poorly conserved C-terminal tail is also found in vertebrates.