Figure 1.

Fold and topology of SAM binding proteins. Corresponding fragments of cartoon and topology representations of selected structures were rainbow colored from N-terminal (blue) to C-terminal (red) end. Less significant fragments of secondary structure were left white in topology diagrams. Reference to other representative structures are provided (in parentheses) as SCOP sunid numbers (i.e. ref. [139]). (a) 1ej0A, Rossmann-fold methyltransferase (53335 excluding: 102555, 69556, 69557, and 69560); (b) 1l1eA, cyclopropane fatty acid synthase (69560); (c) 1mjfA, spermidine synthase (69557); (d) 1vhvA, porphyrin C-methyltransferase (53789); (e) 1j6rB, Met synthase reactivation domain (methyltransferase; 56506); (f) 1mxiA, SPOUT methyltransferase (89629, 75218); (g) 1r30A, SAM dependent radical enzyme (102114); (h) 1mvhA, SET domain methyltransferase (82199); (i) 1rqpB, 5'-fluoro-5'-deoxyadenosine synthase (102521, 101851); (j) 1m7y, 1-aminocyclopropane-1-carboxylate (ACC) synthase (53441, 64130, and similar but different: 53439); (k) 1vkyA, tRNA-ribosyl transferase-isomerase (111338); (l) 1o9tB, methionine adenosyltransferase (55972); (m) 1cmc, MetJ – methionine repressor (dimer; 100972); (n) 1msvA, SAM decarboxylase (56275); (o) 1pbjA, CBS domain (dimer; 54630 – not all CBS domains bind SAM); (p) 1kzfA, acyl-homoserine lactone synthase (75508).

Kozbial and Mushegian BMC Structural Biology 2005 5:19   doi:10.1186/1472-6807-5-19
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