|
Comparison of predicted and experimental changes in aggregation for IAPP variants, relative to the corresponding human IAPP sequence. |
||
| Variant |
ΔAP* |
Observed aggregation‡ |
|
|
||
| (20–29) Cat |
-5.12 |
= |
| (20–29) Rat |
-16.46 |
- |
| (20–29) Hamster |
-32.73 |
- |
| R18H |
+0.94 |
+ |
| L23F |
+1.70 |
+ |
| V26I |
+0.42 |
+ |
| R18H+L23F+V26I |
+3.06 |
+ |
| (22–27) N22A |
+31.53 |
+ |
| (22–27) F23A |
-42.96 |
- |
| (22–27) G24A |
+11.96 |
+ |
| (22–27) I26A |
-44.5872 |
- |
| (22–27) L27A |
-33.99 |
- |
| S20G |
-1.09 |
+ |
| ProIAPP |
+31.40 |
+? |
|
* Change in average aggregation propensity ‡ Changes in aggregation determined experimentally. ? Not yet proved experimentally. | ||
de Groot et al. BMC Structural Biology 2005 5:18 doi:10.1186/1472-6807-5-18 |
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