NA inhibitors. A, Zanamivir; B, oseltamivir; C, Inhibitor 1 (compound 14 of Brouillette et al. ); D, Inhibitor 2; E, The NA subsites that surround the transition state analog 2-deoxy-2-dehydro-N-acetylneuraminic acid (DANA). Note that in the benzoic acid series, subsite 6 is adjacent to C4 of the benzene ring. Figure made with PDB ID: 1NNB.
Venkatramani et al. BMC Structural Biology 2012 12:7 doi:10.1186/1472-6807-12-7