Email updates

Keep up to date with the latest news and content from BMC Structural Biology and BioMed Central.

Open Access Research article

Comparison of tertiary structures of proteins in protein-protein complexes with unbound forms suggests prevalence of allostery in signalling proteins

Lakshmipuram S Swapna1, Swapnil Mahajan23, Alexandre G de Brevern456 and Narayanaswamy Srinivasan1*

Author Affiliations

1 Molecular Biophysics Unit, Indian Institute of Science, Bangalore, 560012, India

2 Univ de la Réunion, UMR_S 665, F-97715, Saint-Denis, France

3 INSERM, U 665, Saint-Denis, F-97715, France

4 INSERM, U 665 DSIMB, Paris, F-75739, France

5 Univ Paris Diderot, Sorbonne Paris Cité, Paris, F- 75739, France

6 INTS, F-75739, Paris, France

For all author emails, please log on.

BMC Structural Biology 2012, 12:6  doi:10.1186/1472-6807-12-6

Published: 3 May 2012

Additional files

Additional file 1:

Table S1. List of PDB codes of structures of control datasets used in this analysis.

Format: PDF Size: 13KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 2:

Table S2. Details of various features of PPC dataset.

Format: XLSX Size: 19KB Download file

Open Data

Additional file 3:

Figure S1. Distribution of parameters capturing structural change for Control and Test datasets.

Format: PDF Size: 727KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 4:

Figure S2. Distribution of parameters capturing structural change with respect to ‘interface area’ and ‘length of protein’.

Format: PDF Size: 136KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 5:

Figure S3. Distribution of all-atom RMSD values for PPC dataset.

Format: PDF Size: 241KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 6:

Figure S4. Different kinds of interfaces.

Format: PDF Size: 1.2MB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 7:

Figure S5. Parameters for identifying rigid-body movements.

Format: PDF Size: 263KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 8:

Figure S6. Different types of structural changes seen at interfaces.

Format: PDF Size: 1002KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 9:

Figure S7. Distribution of parameters for interface vs. non-interacting surface regions per protein.

Format: PDF Size: 319KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 10:

Table S3. Details of non-interacting surface residues with PB change in Case 1 complexes.

Format: XLSX Size: 19KB Download file

Open Data

Additional file 11:

Table S4. Details of non-interacting surface residues with PB change in Case 2 complexes.

Format: XLS Size: 29KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data