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Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme’s active site closure

Jaeok Park, Yih-Shyan Lin, Joris W De Schutter, Youla S Tsantrizos and Albert M Berghuis*

BMC Structural Biology 2012, 12:32  doi:10.1186/1472-6807-12-32