|Dimer interface residues in PKR that are mimicked by the residues in HCV NS5A|
|Nature of interaction||Dimer interface residues of PKR||Equivalent residues in NS5A|
|D266 (Ionic interaction)||R262||S249|
|R262 (Ionic interaction)||D266||D253|
|C326 (Hydrogen bond : NE2 of His with O of Cys )||H286||T270|
|Y300, V309 (Hydrophobic interaction)||I288||V272|
|Y323 (Hydrogen bond: OD2 of Asp with OH of Tyr)||D289||E273|
|I288, V309 (Hydrophobic interaction)||Y300||F284|
The equivalent residues in NS5A to the PKR dimer interface residues are obtained from the pairwise alignment as shown in the Figure 6. The equivalent residues in NS5A which are capable of interacting with PKR mimics the binding of PKR protomer to the other PKR protomer due to the shared binding region of NS5A and PKR protomer with another PKR protomer .
Sudha et al.
Sudha et al. BMC Structural Biology 2012 12:28 doi:10.1186/1472-6807-12-28