Table 1 |
|||||
| Additional conserved motifs observed in heavy metal transporter P-type ATPases | |||||
| Phylogenetic subgroup | Cation specificity | TMS6 | TMS7 | TMS8 | MTBC pump |
| PIB-1 | Cu+ | CPC | YN | MXXSS | CtpA |
| CtpB | |||||
| CtpV | |||||
| PIB-2 | Zn2+ | CPC(X)4S | K | DG | CtpC * |
| PIB-3 | Cu2+ | CPH | YN | MXXS | - |
| PIB-4 | Co2+ | SCP | N | HEGT | CtpD * |
| CtpJ * | |||||
| PIB-5 | Undetermined | TPCP | QX4GX3SX3M | PX5QEX2DX5N | - |
The additional motifs are located on TMS6, TMS7 and TMS8. *, pumps without a complete set of motifs (see discussion).
Novoa-Aponte et al. BMC Structural Biology 2012 12:25 doi:10.1186/1472-6807-12-25
