Table 1

Additional conserved motifs observed in heavy metal transporter P-type ATPases
Phylogenetic subgroup Cation specificity TMS6 TMS7 TMS8 MTBC pump
PIB-1 Cu+ CPC YN MXXSS CtpA
CtpB
CtpV
PIB-2 Zn2+ CPC(X)4S K DG CtpC *
PIB-3 Cu2+ CPH YN MXXS -
PIB-4 Co2+ SCP N HEGT CtpD *
CtpJ *
PIB-5 Undetermined TPCP QX4GX3SX3M PX5QEX2DX5N -

The additional motifs are located on TMS6, TMS7 and TMS8. *, pumps without a complete set of motifs (see discussion).

Novoa-Aponte et al.

Novoa-Aponte et al. BMC Structural Biology 2012 12:25   doi:10.1186/1472-6807-12-25

Open Data