Classification of P-type ATPases of M. tuberculosis H37Rv according to ion specificity. Amino acid sequences of M. tuberculosis H37Rv P-type ATPases were compared with the HMM profiles built from characterized P-type ATPases reported by Uniprot. Grouping is based on the scores obtained from Hmmsearch. HM group (blue bars) includes the P-type ATPase transporters of heavy metals (CtpA, CtpB, CtpC, CtpD, CtpG, CtpJ, CtpV). The EAM group (red bars) includes transporters of alkaline and alkaline earth metals (CtpE, CtpF, CtpH, CtpI). The KdpB group (purple bars) includes the β subunit of K+ P-type ATPase. The scores obtained from the Hmmsearch tool are shown in the bottom of each plot.
Novoa-Aponte et al. BMC Structural Biology 2012 12:25 doi:10.1186/1472-6807-12-25