Figure 6.

3-Aminoindazoles stabilize an open conformation of the Tyk2 glycine-rich loop. The chlorophenyl group of Compound 1 occupies hydrophobic pocket under the glycine rich loop. Overlay of mouse Tyk2 /Compound 2 (tan) and human Tyk2/CMP-6 (PDB entry 3LXP, cyan) structures. Deviation in the positioning of the glycine-rich loop tip is demonstrated.

Argiriadi et al. BMC Structural Biology 2012 12:22   doi:10.1186/1472-6807-12-22
Download authors' original image