Co-evolutionary distance correlates with physical distance. The figure shows the distances for the subunits in the evolutionary conserved core in T. thermophilus (PDB:3M9S). Note that in the bacterial structure NADH3, 4L and 6 were not identified individually but are neighboring. Therefore, we calculated the co-evolutionary distances with concatenated alignments of these subunits. The red line is the regression line for the matrix arm and the black line is the regression line for the complete set of points.
Kensche et al. BMC Structural Biology 2012 12:19 doi:10.1186/1472-6807-12-19