Additional file 1.

Figure SA. The average and median sensitivities of the functional region predictions generated by 18 different criteria for sequence selection. The horizontal axis represents the sequence selection methods, DSPAC-based method, SDPfox, and Naïve approaches, with 16 different percent sequence identity thresholds. The red open rectangles with error bars indicate the averaged sensitivities of the predictions when LMIC was used to detect the cluster of conserved residues. The negative part of the error bar, which would extend into the region of negative sensitivity, is not drawn, since the sensitivity has a positive value by definition. The light green open triangles indicate the medians of the predictions when LMIC was used to detect the cluster of conserved residues. The blue crosses with error bars indicate the averaged sensitivities of the predictions when PatchFinder was used to detect the cluster of conserved residues. The purple asterisks indicate the median sensitivities of the predictions when PatchFinder was used to detect the cluster of conserved residues.

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Nemoto and Toh BMC Structural Biology 2012 12:11   doi:10.1186/1472-6807-12-11