Email updates

Keep up to date with the latest news and content from BMC Structural Biology and BioMed Central.

Open Access Highly Accessed Research article

1,000 structures and more from the MCSG

David Lee1*, Tjaart AP de Beer2, Roman A Laskowski2, Janet M Thornton2 and Christine A Orengo1

Author Affiliations

1 Department of Structural and Molecular Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK

2 European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK

For all author emails, please log on.

BMC Structural Biology 2011, 11:2  doi:10.1186/1472-6807-11-2

Published: 10 January 2011

Abstract

Background

The Midwest Center for Structural Genomics (MCSG) is one of the large-scale centres of the Protein Structure Initiative (PSI). During the first two phases of the PSI the MCSG has solved over a thousand protein structures. A criticism of structural genomics is that target selection strategies mean that some structures are solved without having a known function and thus are of little biomedical significance. Structures of unknown function have stimulated the development of methods for function prediction from structure.

Results

We show that the MCSG has met the stated goals of the PSI and use online resources and readily available function prediction methods to provide functional annotations for more than 90% of the MCSG structures. The structure-to-function prediction method ProFunc provides likely functions for many of the MCSG structures that cannot be annotated by sequence-based methods.

Conclusions

Although the focus of the PSI was structural coverage, many of the structures solved by the MCSG can also be associated with functional classes and biological roles of possible biomedical value.