Research article
A kinesin motor in a force-producing conformation
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* Corresponding author: Sharyn A Endow endow@duke.edu
1 Department of Chemistry, Dartmouth College, Hanover, NH 03755 USA
2 Department of Cell Biology, Duke University, Durham, NC 27710 USA
BMC Structural Biology 2010, 10:19 doi:10.1186/1472-6807-10-19
Published: 5 July 2010Additional files
Additional file 1:
Supplementary Figures. 1) Figure S1 shows that there is a difference in the ADP density in the two heads of the NcdT436S model consistent with the occurrence of stalk rotation with ADP release; it is reduced in the head of chain B that is positioned to bind to the microtubule compared to the head of chain A. 2) Figure S2 shows the kinesin-1 neck linker and Ncd neck mimic, together with a diagram of their positions in the two motors and a diagram of an Ncd motor with the neck mimic replaced by the kinesin-1 neck linker that showed minus-end motility.
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