Setting the standard for SAS

Jill Trewhella and colleagues describe the rationale behind guidelines recently issued by The International Union of Crystallography for the reporting of biomolecular structures derived from Small-Angle Scattering (SAS) data.

Tilting influenza neuraminidase inhibitors

The crystal structure of a novel benzoic acid inhibitor of influenza neuraminidase reveals an increased number of contacts compared to previous inhibitors, due to a tilt in the position of the benzene ring that maximizes these interactions.

Oligomerization of Plasmodium peroxiredoxins

Structural characterization of peroxiredoxins from Plasmodium species identifies the novel toroid octameric oligomer of PyTrx-Px1 and confirms that PvTrx-Px1 is a hydrogen peroxide-sensitive peroxiredoxin, which may aid targeting of these antioxidant enzymes in drug design

Modeling protein/DNA complexes in cyanobacteria

A 3D structure of the complex between the PerR-like regulator Slr1738 and its target DNA, which controls metal and oxidative stress response in the cyanobaterium Synechocystis, provides insight into stability and recognition in protein-DNA interactions

Novel non-proline-containing CypA binding motif

Identification of a region of HIV-1 Vpr which binds specifically to the host cellular factor CypA with similar affinity to full-length Vpr is the first such binding domain described that involves no proline residues.