Short circuit current and balance in CFTR knockout mice. (top panel) Vibrating Probe recordings of Isc from native SCCD from heterozygote (CFTR+/−) and CFTR knockout (CFTR−/−) mice (n=3 each). ISO, Isoproterennol (10 μM); F, Forskolin; I, IBMX; D, DIOA; B, Bumetanide. The control bath solution contained Amiloride (10 μm). Perfusion was returned to control solution after isoproterenol. *, significant change in current by treatment; P < 0.05. NS, not significant. (bottom panel) Balance function of heterozygote (CFTR+/−) and CFTR knockout (CFTR−/−) mice was tested with a rota-rod apparatus. No significant difference was found between the two groups (n=5 each).
Pondugula et al. BMC Physiology 2013 13:6 doi:10.1186/1472-6793-13-6