Hyperglycemic (HG) clamp in anesthetized DIO and lean mice. The HG clamps were performed over a 90 min period as previously described , with the exception of modifications described in the methods section. The hyperglycemic target was 300 mg/dl. Changes in plasma insulin concentration during HG clamp: first phase (A) and second phase (B); glucose infusion rate (C). Data are the means ± SE n = 6-8/group. *p < 0.05 vs. lean mice.
Qi et al. BMC Physiology 2011 11:1 doi:10.1186/1472-6793-11-1