Table 3

Regulatory factors involved in the coagulation cascade and lipid metabolism in zebrafish and mammalian obesity

Coagulation cascade

Zebrafish

Rat

Mouse

Human


Regulatory factor

p-value

Ranka

p-value

Ranka

p-value

Ranka

p-value

Ranka


APOH

1.9E-08

1

8.4E-16

1

2.4E-12

2

9.1E-11

4


IL-6

4.6E-05

3

6.5E-10

5

8.2E-09

7

4.5E-10

6


IL-1β

7.0E-05

6

1.2E-08

8

1.6E-07

16

8.4E-09

9



Lipid metabolism

Zebrafish

Rat

Mouse

Human


Regulatory factor

p-value

Ranka

p-value

Ranka

p-value

Ranka

p-value

Ranka


PPARα

1.6E-10

1

1.1E-23

1

9.1E-19

1

6.9E-24

1


PPARγ

1.7E-10

2

1.7E-15

3

2.1E-14

2

1.1E-16

3


NR1H3

1.0E-06

5

1.6E-15

2

2.7E-12

5

5.8E-17

2


LEP

1.8E-05

9

4.1E-10

13

3.7E-09

8

3.6E-12

10


SREBF1

1.8E-03

36

2.8E-13

7

5.7E-10

7

9.9E-10

15


aRegulatory factors are ranked based on the p-value in each dataset.

Regulatory factors ranked within the top 15 in at least three datasets are shown in this table.

Oka et al. BMC Physiology 2010 10:21   doi:10.1186/1472-6793-10-21

Open Data