Open Access Highly Accessed Research article

Identification of differences in human and great ape phytanic acid metabolism that could influence gene expression profiles and physiological functions

Paul A Watkins1, Ann B Moser1, Cicely B Toomer1, Steven J Steinberg1, Hugo W Moser1, Mazen W Karaman2, Krishna Ramaswamy2, Kimberly D Siegmund3, D Rick Lee4, John J Ely4, Oliver A Ryder5 and Joseph G Hacia2*

Author Affiliations

1 Hugo W. Moser Research Institute at Kennedy Krieger, and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA

2 Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, CA, 90089, USA

3 Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90089, USA

4 Alamogordo Primate Facility, New Mexico, NM 88330, USA

5 Institute for Conservation and Research, Zoological Society of San Diego, Escondido, CA 92027, USA

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BMC Physiology 2010, 10:19  doi:10.1186/1472-6793-10-19

Published: 8 October 2010

Additional files

Additional file 1:

Composition of blood donor cohort. A summary of the numbers, ages, and sex of blood donors is provided.

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Additional file 2:

Skin fibroblast cultures used for phytanic and pristanic acid biochemical analysis. A summary of donor sex and age and anatomical source of the skin fibroblasts is provided.

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Additional file 3:

Detailed summary of gene expression data for cross-species comparisons. More complete gene expression data summary statistics relevant to Figure 4 are provided.

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Additional file 4:

Phytanic acid levels relative to total fatty acids in red blood cells from individual donors. Relative phytanic acid levels for all RBC donors are provided.

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Additional file 5:

Rates of phytanic and pristanic acid oxidation in cultured dermal fibroblasts. The rates of phytanic and pristanic acid oxidation from all individual fibroblast cultures are provided.

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