Table 3

KEGG pathways significantly enriched in target proteins.a

Pathway Name

Corrected p-value

Number of target proteins selected

Total number of proteins in pathway

Fraction of population as targets


Glycolysis/Gluconeogenesis

2.96E-08

12

45

0.267

Glutathione metabolism

1.25E-06

9

30

0.300

Carbon fixation

9.92E-06

7

19

0.368

Pyruvate metabolism

1.25E-05

8

29

0.276

Urea cycle and metabolism of amino groups

1.38E-05

7

20

0.350

Arginine and proline metabolism

5.63E-05

7

25

0.280

Metabolism of xenobiotics by cytochrome P450

7.13E-05

9

50

0.180

Limonene and pinene degradation

2.70E-04

5

12

0.417

Propanoate metabolism

4.02E-04

6

23

0.261

Glutamate metabolism

4.97E-04

6

24

0.250

Phenylalanine metabolism

6.97E-04

5

15

0.333

3-Chloroacrylic acid degradation

7.50E-04

4

7

0.571

Fatty acid metabolism

8.59E-04

7

40

0.175

Nitrogen metabolism

9.09E-04

5

16

0.313

Cysteine metabolism

9.09E-04

5

16

0.313


aPathway mapping was performed using DAVID, and 101 of 171 target proteins could be mapped to one or more KEGG pathways. The subset of rat proteins that are allocable to KEGG pathways includes 3396 proteins.

Fang et al. BMC Chemical Biology 2009 9:5   doi:10.1186/1472-6769-9-5

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