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Open Access Research article

Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners

Jianwen Fang1, Yakov M Koen2 and Robert P Hanzlik2*

Author Affiliations

1 Applied Bioinformatics Laboratory, University of Kansas, Lawrence, KS 66045, USA

2 Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66045, USA

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BMC Chemical Biology 2009, 9:5  doi:10.1186/1472-6769-9-5

Published: 12 June 2009

Additional files

Additional file 1:

Figure S1. Graphic representation of enriched GO Biological Process categories and their hierarchical structure of the 171 target proteins. Heirarchial tree diagram showing the names and relationships of the GO Biological Process categories in which members of a set of 171 reactive metabolite target proteins are statistically over-represented.

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Additional file 2:

Figure S2. Graphic representation of enriched GO Molecular Function categories and their hierarchical structure of the 171 target proteins. Heirarchial tree diagram showing the names and relationships of the GO Molecular Function categories in which members of a set of 171 reactive metabolite target proteins are statistically over-represented.

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Additional file 3:

Table S1. Human orthologs of 28 common rat/mouse target proteins. Accession numbers of 28 common rat/mouse target proteins and their human orthologs, and their degree of similarity.

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Additional file 4:

Table S2. First-partners of 28 common target proteins. Accession numbers of 28 common rat/mouse target proteins and their human orthologs, and their degree of similarity. Accession numbers and gene symbols of the 165 directly-interacting partners found for 28 common rat and mouse target proteins.

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Additional file 5:

Table S3. Significantly over-populated GO terms. GO ID numbers and names of Molecular Function, Biological Process and Cellular Component categories in which members of a set of 171 reactive metabolite target proteins are statistically over-represented.

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