Table 1 |
|||
|
Kinase selectivity profiling of QAP 1 in radiometric filter binding assays |
|||
|
Kinase |
IC50 (μM) |
Kinase |
IC50 (μM) |
|
|
|||
|
HER-1 |
> 10 |
FGFR3-K560E |
> 10 |
|
|
|||
|
KDR |
> 10 |
Axl |
> 10 |
|
|
|||
|
Flt-3 |
> 10 |
Fak |
> 10 |
|
|
|||
|
IGF-1R |
> 10 |
c-Abl |
> 10 |
|
|
|||
|
Tek |
> 10 |
c-Abl-T315I |
> 10 |
|
|
|||
|
c-Src |
1.7 ± 0.5 |
PKA |
> 10 |
|
|
|||
|
c-Met |
> 10 |
CDK1/CycB |
> 10 |
|
|
|||
|
Ret |
1.35 ± 0.05 |
PKB |
> 10 |
|
|
|||
|
Jak2 |
> 10 |
PDK1 |
> 10 |
|
|
|||
|
EphB4 |
> 10 |
BRAF-V600E |
> 10 |
|
|
|||
|
QAP 1 was profiled against a panel of serine/threonine/tyrosine protein kinases. Data typically represent means of two independent experiments ± SD. |
|||
|
Chène et al. BMC Chemical Biology 2009 9:1 doi:10.1186/1472-6769-9-1 |
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