Email updates

Keep up to date with the latest news and content from BMC Chemical Biology and BioMed Central.

Open Access Highly Accessed Research article

Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol

Zoltan Maliga1* and Timothy J Mitchison2

Author Affiliations

1 MPI-CBG, Pfotenhauer Strasse 108, 01307 Dresden, Germany

2 Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA

For all author emails, please log on.

BMC Chemical Biology 2006, 6:2  doi:10.1186/1472-6769-6-2

Published: 27 February 2006

Additional files

Additional File 1:

Atomic structure determination of the Eg5-monastrol-ADP complex using multi-wavelength anomalous dispersion (PDB 1X88). Materials and methods for determination of Eg5-monastrol-ADP co-crystal structure using selenomethionine-labeled Eg5 motor domain as independent verification of published structure [25].

Format: DOC Size: 34KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional File 2:

Crystallographic data and refinement statistics for structure of Eg5-monastrol-ADP complex (PDB: 1X88).

Format: TIFF Size: 2.1MB Download file

Open Data