Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol
1 MPI-CBG, Pfotenhauer Strasse 108, 01307 Dresden, Germany
2 Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA
BMC Chemical Biology 2006, 6:2 doi:10.1186/1472-6769-6-2Published: 27 February 2006
Additional File 1:
Atomic structure determination of the Eg5-monastrol-ADP complex using multi-wavelength anomalous dispersion (PDB 1X88). Materials and methods for determination of Eg5-monastrol-ADP co-crystal structure using selenomethionine-labeled Eg5 motor domain as independent verification of published structure .
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Additional File 2:
Crystallographic data and refinement statistics for structure of Eg5-monastrol-ADP complex (PDB: 1X88).
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