Table 3

Correlations between electronic properties and folding preferencesa.

Index

HNNMR

σI

σR

σα

σF

AI

CαMULL


Kyte-Doolittle

-0.8**

0

0

-0.2

0.3

-0.5*

0.4

Water vapor

0.8**

0.2

0.2

0.1

-0.6*

0.5*

-0.4

Bulk

-0.3

-0.1

-0.2

0.9**

0

0.2

-0.4

Gyration

-0.2

0

-0.2

0.9**

0

0.3

-0.5*

α-helix

-0.1

0.3

0.1

0.2

-0.2

0.6**

-0.7**

β-strand

-0.8**

-0.2

-0.1

0.3

0.3

-0.4

0.2

coil

0.7**

0.1

0.4

-0.3

-0.4

0.3

-0.3

eσ

-0.1

-0.9**

-0.9**

0.3

0.7**

-0.6**

0.4

pKa

-0.1

0.3

0.3

-0.3

0.1

0

0

σI

0.2

σR

0.2

0.8**

σα

-0.4

-0.1

-0.2

σF

-0.4

-0.8**

-0.9**

0

AI

0.5*

0.7**

0.5*

0

-0.6**

CαMULL

-0.2

-0.6*

-0.4

-0.2

0.5*

-0.8**


aLinear regression analysis was performed to determine possible correlations between the various electronic scales presented here. The first 2 indices of hydrophobicity were taken from Kyte and Doolittle [46], the bulk scale was from Kidera et al. [38], and the gyration scale is that of Levitt [39]. The secondary structure preferences and eσ scales were described previously [8]. The r values from the analysis are presented here and directions of the slope are indicated by the signs. Statistical analysis of the data revealed significant correlations: *p < 0.05, **p < 0.01.

Dwyer BMC Chemical Biology 2005 5:2   doi:10.1186/1472-6769-5-2

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