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Editor-in-Chief Melissa Norton, MD
Biology Editor Penelope Webb, PhD
In-house Editor Danielle Burgess PhD
Welcome to BMC Chemical Biology published by BioMed Central
BMC Chemical Biology is an open access journal publishing original peer-reviewed research articles in the application of chemistry to the investigation of biological processes and systems including the biosynthesis and metabolism of natural compounds, drug design and complex molecular rearrangements occurring in living organisms.
BMC Chemical Biology (ISSN 1472-6769) is indexed/tracked/covered by PubMed, BIOSIS, CAS, EMBASE, Scopus and Google Scholar.
Featured articles
BMC Chemical Biology 2009, 9 :7
Treatment of primary human endothelial cells with tumoral soluble factors induces a pro-adhesive endothelial phenotype and the expression of three new isoforms of the cell adhesion molecule VCAM-1, which could serve as markers of metastasis.
BMC Chemical Biology 2009, 9 :6
A fast, automated and reliable program for generating the 3D conformation of small molecules facilitates the preparation of compounds for the in silico screening methods of drug discovery.
BMC Chemical Biology 2009, 9 :5
Proteins with high lysine content and high turnover are more susceptible to covalent modification by xenobiotic reactive metabolites, and an analysis of directly-interacting partners of the most common known targets suggests how adduction has toxic effects.
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Research article
Glycosylated VCAM-1 isoforms revealed in 2D westerns of HUVECs treated with tumoral soluble factors of breast cancer cells
Delina Montes-Sanchez, Jose Luis Ventura, Irma Mitre, Susana Frias, Layla Michan, Aurora Espejel-Nunez, Felipe Vadillo-Ortega, Alejandro Zentella BMC Chemical Biology 2009, 9 :7 (22 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Software
DG-AMMOS: A New tool to generate 3D conformation of small molecules using D istance G eometry and A utomated M olecular M echanics O ptimization for in silico S creening David Lagorce, Tania Pencheva, Bruno O Villoutreix, Maria A Miteva BMC Chemical Biology 2009, 9 :6 (13 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners Jianwen Fang, Yakov M Koen, Robert P Hanzlik BMC Chemical Biology 2009, 9 :5 (12 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Local and global modes of drug action in biochemical networks Jean-Marc Schwartz, Jose C Nacher BMC Chemical Biology 2009, 9 :4 (7 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Methodology article
Chemical tools selectively target components of the PKA system Daniela Bertinetti, Sonja Schweinsberg, Susanne E Hanke, Frank Schwede, Oliver Bertinetti, Stephan Drewianka, Hans-Gottfried Genieser, Friedrich W Herberg BMC Chemical Biology 2009, 9 :3 (12 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus John Paul Pezacki, Selena M Sagan, Angela M Tonary, Yanouchka Rouleau, Sylvie B BMC Chemical Biology 2009, 9 :2 (16 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue Patrick Ch BMC Chemical Biology 2009, 9 :1 (7 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Chemogenetic fingerprinting by analysis of cellular growth dynamics Jonas Warringer, Dragi Anevski, Beidong Liu, Anders Blomberg BMC Chemical Biology 2008, 8 :3 (22 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II Maria H BMC Chemical Biology 2008, 8 :2 (1 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Identification of cellular pathways affected by Sortin2, a synthetic compound that affects protein targeting to the vacuole in Saccharomyces cerevisiae Lorena Norambuena, Jan Zouhar, Glenn R Hicks, Natasha V Raikhel BMC Chemical Biology 2008, 8 :1 (7 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research
Exogenous incorporation of neuGc-rich mucin augments N-glycolyl sialic acid content and promotes malignant phenotype in mouse tumor cell lines Mariano R Gabri, Laura L Otero, Daniel E Gomez, Daniel F Alonso Journal of Experimental & Clinical Cancer Research 2009, 28 :146 (1 [Abstract ] [Provisional PDF ]
Research
Human male gamete endocrinology: 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) regulates different aspects of human sperm biology and metabolism Saveria Aquila, Carmela Guido, Emilia Middea, Ida Perrotta, Rosalinda Bruno, Michele Pellegrino, Sebastiano Ando' Reproductive Biology and Endocrinology 2009, 7 :140 (30 [Abstract ] [Provisional PDF ]
Editorial
PARP inhibitors and the treatment of breast cancer: beyond BRCA1/2 ? Kristine M Frizzell, W Lee Kraus Breast Cancer Research 2009, 11 :111 (26 [PDF ]
Methodology
A rapid and sensitive method for the simultaneous analysis of aliphatic and polar molecules containing free carboxyl groups in plant extracts by LC-MS/MS Mario Kallenbach, Ian T Baldwin, Gustavo Bonaventure Plant Methods 2009, 5 :17 (25 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Short report
The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation John P Alao, Per Sunnerhagen Radiation Oncology 2009, 4 :51 (10 [Abstract ] [Full Text ] [PDF ] [PubMed ] [Related articles ]
Research article
Biosynthesis of the proteasome inhibitor syringolin A: the ureido group joining two amino acids originates from bicarbonate Christina Ramel, Micha Tobler, Martin Meyer, Laurent Bigler, Marc-Olivier Ebert, Barbara Schellenberg, Robert Dudler BMC Biochemistry 2009, 10 :26 (28 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research
Breaking the hierarchy - a new cluster selection mechanism for hierarchical clustering methods L Algorithms for Molecular Biology 2009, 4 :12 (19 [Abstract ] [Full Text ] [PDF ] [PubMed ] [Related articles ]
Research article
Combination of interferon-alpha and 5-fluorouracil inhibits endothelial cell growth directly and by regulation of angiogenic factors released by tumor cells Hiroshi Wada, Hiroaki Nagano, Hirofumi Yamamoto, Takehiro Noda, Masahiro Murakami, Shogo Kobayashi, Shigeru Marubashi, Hidetoshi Eguchi, Yutaka Takeda, Masahiro Tanemura, Koji Umeshita, Yuichiro Doki, Masaki Mori BMC Cancer 2009, 9 :361 (12 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Conformational changes and loose packing promote E. coli Tryptophanase cold lability Anna Kogan, Garik Y Gdalevsky, Rivka Cohen-Luria, Yehuda Goldgur, Robert S Phillips, Abraham H Parola, Orna Almog BMC Structural Biology 2009, 9 :65 (8 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Review
Eps15: a multifunctional adaptor protein regulating intracellular trafficking Paul MP van Bergen en Henegouwen Cell Communication and Signaling 2009, 7 :24 (8 [Abstract ] [Full Text ] [PDF ] [PubMed ] [Related articles ]
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