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Editor-in-Chief Melissa Norton, MD
Biology Editor Penelope Webb, PhD
In-house Editor Danielle Burgess PhD
Welcome to BMC Chemical Biology published by BioMed Central
BMC Chemical Biology is an open access journal publishing original peer-reviewed research articles in the application of chemistry to the investigation of biological processes and systems including the biosynthesis and metabolism of natural compounds, drug design and complex molecular rearrangements occurring in living organisms.
BMC Chemical Biology (ISSN 1472-6769) is indexed/tracked/covered by PubMed, BIOSIS, CAS, EMBASE, Scopus and Google Scholar.
BMC Chemical Biology 2009, 9 :7
Treatment of primary human endothelial cells with tumoral soluble factors induces a pro-adhesive endothelial phenotype and the expression of three new isoforms of the cell adhesion molecule VCAM-1, which could serve as markers of metastasis.
BMC Chemical Biology 2009, 9 :6
A fast, automated and reliable program for generating the 3D conformation of small molecules facilitates the preparation of compounds for the in silico screening methods of drug discovery.
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Research article
Glycosylated VCAM-1 isoforms revealed in 2D western blots of HUVECs treated with tumoral soluble factors of breast cancer cells Delina Montes-S BMC Chemical Biology 2009, 9 :7 (22 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Software
DG-AMMOS: A New tool to generate 3D conformation of small molecules using D istance G eometry and A utomated M olecular M echanics O ptimization for in silico S creening David Lagorce, Tania Pencheva, Bruno O Villoutreix, Maria A Miteva BMC Chemical Biology 2009, 9 :6 (13 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners Jianwen Fang, Yakov M Koen, Robert P Hanzlik BMC Chemical Biology 2009, 9 :5 (12 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Local and global modes of drug action in biochemical networks Jean-Marc Schwartz, Jose C Nacher BMC Chemical Biology 2009, 9 :4 (7 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Methodology article
Chemical tools selectively target components of the PKA system Daniela Bertinetti, Sonja Schweinsberg, Susanne E Hanke, Frank Schwede, Oliver Bertinetti, Stephan Drewianka, Hans-Gottfried Genieser, Friedrich W Herberg BMC Chemical Biology 2009, 9 :3 (12 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus John Paul Pezacki, Selena M Sagan, Angela M Tonary, Yanouchka Rouleau, Sylvie B BMC Chemical Biology 2009, 9 :2 (16 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue Patrick Ch BMC Chemical Biology 2009, 9 :1 (7 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Chemogenetic fingerprinting by analysis of cellular growth dynamics Jonas Warringer, Dragi Anevski, Beidong Liu, Anders Blomberg BMC Chemical Biology 2008, 8 :3 (22 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II Maria H BMC Chemical Biology 2008, 8 :2 (1 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Identification of cellular pathways affected by Sortin2, a synthetic compound that affects protein targeting to the vacuole in Saccharomyces cerevisiae Lorena Norambuena, Jan Zouhar, Glenn R Hicks, Natasha V Raikhel BMC Chemical Biology 2008, 8 :1 (7 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research
Activity-based protein profiling of the hepatitis C virus replication in Huh-7 hepatoma cells using a non-directed active site probe Ragunath Singaravelu, David R Blais, Craig S McKay, John Paul Pezacki Proteome Science 2010, 8 :5 (4 [Abstract ] [Provisional PDF ]
Review
Aptamer-targeted cell-specific RNA interference Jiehua Zhou, John J Rossi Silence 2010, 1 :4 (1 [Abstract ] [Provisional PDF ]
Software review
Dockres: a computer program that analyzes the output of virtual screening of small molecules
Mihaly Mezei, Ming-Ming Zhou Source Code for Biology and Medicine 2010, 5 :2 (14 [Abstract ] [Provisional PDF ]
Research
Differential effect of maternal diet supplementation with Fr Nutrition & Metabolism 2010, 7 :2 (14 [Abstract ] [Full Text ] [PDF ]
Research
Design and pre-clinical profiling of a Plasmodium falciparum MSP-3 derived component for a multi-valent virosomal malaria vaccine Marco Tamborrini, Markus S Mueller, Sabine A Stoffel, Nicole Westerfeld, Denise Vogel, Francesca Boato, Rinaldo Zurbriggen, John A Robinson, Gerd Pluschke Malaria Journal 2009, 8 :314 (30 [Abstract ] [Full Text ] [PDF ] [PubMed ] [Related articles ]
Methodology article
Model system for the analysis of cell surface expression of human ABCA1 Ildik BMC Cell Biology 2009, 10 :93 (21 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Methodology article
Crossfit analysis: a novel method to characterize the dynamics of induced plant responses Jeroen J Jansen, Nicole M van Dam, Huub CJ Hoefsloot, Age K Smilde BMC Bioinformatics 2009, 10 :425 (16 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
The hemolytic and cytolytic activities of Serratia marcescens phospholipase A (PhlA) depend on lysophospholipid production by PhlA Ken Shimuta, Makoto Ohnishi, Sunao Iyoda, Naomasa Gotoh, Nobuo Koizumi, Haruo Watanabe BMC Microbiology 2009, 9 :261 (16 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Biochemical evidence for the tyrosine involvement in cationic intermediate stabilization in mouse Eugenia Poliakov, Susan Gentleman, Preethi Chander, Francis X Cunningham Jr, Bella L Grigorenko, Alexander V Nemuhin, T Michael Redmond BMC Biochemistry 2009, 10 :31 (14 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Proteome analysis of Aspergillus niger : Lactate added in starch-containing medium can increase production of the mycotoxin fumonisin B2 by modifying acetyl-CoA metabolism Louise M S BMC Microbiology 2009, 9 :255 (10 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
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