Open Access Highly Accessed Research article

Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid

Dae-Kyun Ro1, Mario Ouellet2, Eric M Paradise3, Helcio Burd2, Diana Eng4, Chris J Paddon4, Jack D Newman4 and Jay D Keasling2356*

Author Affiliations

1 Department of Biological Sciences, University of Calgary, Calgary, T2N 1N4, Canada

2 California Institute of Quantitative Biomedical Research, University of California, Berkeley, USA

3 Department of Chemical Engineering, University of California, Berkeley, 94720, USA

4 Amyris Biotechnologies, Emeryville, USA

5 Department of Bioengineering, University of California, Berkeley, USA

6 Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, USA

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BMC Biotechnology 2008, 8:83  doi:10.1186/1472-6750-8-83

Published: 4 November 2008

Additional files

Additional file 1:

A list of genes significantly differentially expressed in EPY330 or EPY338. The additional data file includes a processed data set for differentially expressed genes identified by microarray analysis. The data set has 2,156 genes that were significantly differentially expressed in at least one experimental time points and has 488 and 256 genes that were up-regulated and down-regulated, respectively, in the producer strain by more than 2-fold at least one time points.

Format: XLS Size: 675KB Download file

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Open Data