Biosynthesis of C. roseus TIAs. The abbreviations stand for anthranilate synthase (AS), tryptophan decarboxylase (TDC), geraniol-10-hydroxylase (G10H), cytochrome P450 reductase (CPR), secologanin synthase (SLS), strictosidine synthase (STR), strictosidine β-D-glucosidase (SGD), tabersonine-16-hydroxylase (T16H), 16-hydroxytabersonine-16-O-methyltransferase (16-OMT), minovincinine-19-O-acetyltransferase (MAT), desacetoxyvindoline-4-hydroxylase (D4H), deacetylvindoline-4-O-acetyltransferase (DAT), and Peroxidase (PRX). Broken arrows indicate multiple-step or uncharacterized enzymatic conversions.
Wang et al. BMC Biotechnology 2012 12:34 doi:10.1186/1472-6750-12-34