Retention of radiolabeled proteins in experimental thrombi formed in mice or rabbits. (A) The radioactivity remaining in clots induced by surgical, topical application of 10% ferric chloride to the vena cava of anesthetized mice is shown, as a fraction of the total radioactive protein dose injected, divided by the weight of the clot. Injected radiolabeled proteins are identified on the × axis. The mean ± SD of 12 determinations is shown. (B) The radioactivity remaining in rabbit jugular vein clots formed in clamped-off vessels in situ for 30 minutes in the anesthetized animal, then exposed to circulating blood for 60 minutes, prior to clot recovery and γ-counting is shown, expressed as in Figure 6A. The extent (p < 0.001, p < 0.05) of statistical significance is shown for the data sets linked by horizontal lines.
Sheffield and Eltringham-Smith BMC Biotechnology 2011 11:127 doi:10.1186/1472-6750-11-127