Table 2

Whole Blood Rapamycin Levels

24 hours

48 hours


Treatment Groups

Rapamycin Level (ng/ml)

p value*

Number of Mice

Rapamycin Level (ng/ml)

p value**

Number of Mice


Treatment Trial (

    Tumor bearing
)

0.4% Direct Topical Rapamycin

6.3 ± 0.6

0.02

3

2.3 ± 0.4

0.04

3

0.8% Indirect Topical Rapamycin

11.9 ± 3.2

0.92

3

5.3 ± 0.8

0.25

3

0.8% Direct Topical Rapamycin

12.3 ± 1.5

N/A

3

4.1 ± 0.5

N/A

3

0.16 mg Rapamycin IP

55.9 ± 2.7

0.0005

2

17.4 ± 2.2

0.005

2

    Non-Tumor bearing

0.4% Topical Rapamycin (1 dose)

5.9 ± 0.5

0.01

3

1.7 ± 0.9

0.07

3

0.8% Topical Rapamycin (1 dose)

13.0 ± 2.5

0.81

3

4.1 ± 2.3

0.98

3

0.8% Topical Rapamycin + Bandage (1 dose)

3.4 ± 0.6

<0.0001

8

2.6 ± 0.7

0.28

8

0.8% Topical Rapamycin + Collar (3 doses)

21.7 ± 3.7

0.13

6

Not done

N/A

Not done


* Compared to 0.8% direct treatment (tumor bearing) 24 hr blood level.

** Compared to 0.8% direct treatment (tumor bearing) 48 hr blood level

Rauktys et al. BMC Dermatology 2008 8:1   doi:10.1186/1471-5945-8-1

Open Data