Figure 3.

Numbers of positive cells (mean +/- SEM) per square millimeter of α4β1+ (CD49d), CD3+ and CD68+ (A), CCR5+, CXCR3+ and CCR4+ (B) infiltrating cells in antigen-challenged skin biopsies. Negative antigen-challenged sites (Ag-) at 48 h were used as control. Significant differences (Ag- and 2-, 10- and 48-h specific Ag challenge time points; Friedman's test) were observed for CD3+ T lymphocytes (p < 0.0001), CD68+ macrophages (p < 0.0001), CXCR3+ cells (p < 0.003), CCR4+ cells (p < 0.003), and CCR3+ cells (p < 0.003).