Figure 1.

Dose-dependency of reactions. The reactions were classiefied according to Mueller ¹⁰ with grade I – urticaria, pruritus, malaise; grade II – angioedema, chest tightness, nausea, vomiting, abdominal pain, dizziness; grade III – dispnoea, wheeze, stridor, dysphagia, hoarseness, and grade IV – hypotension, collapse, loss of consciousness, incontinence, cyanosis. Black: Mueller I, grey: Mueller II.