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Open Access Highly Accessed Research article

TGFβ signaling regulates lipogenesis in human sebaceous glands cells

Adrian J McNairn, Yanne Doucet, Julien Demaude, Marion Brusadelli, Christopher B Gordon, Armando Uribe-Rivera, Paul F Lambert, Charbel Bouez, Lionel Breton and Géraldine Guasch*

BMC Dermatology 2013, 13:2  doi:10.1186/1471-5945-13-2

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Blimp1 as a sebaceous gland stem cell marker; Crosstalk with TGF-beta signal

Go Yoshida   (2014-07-23 10:17)  School of Medicine, Keio University email

It has recently been reported that Blimp1 is a functional stem cell marker for sebaceous glands. Blimp1 suppresses the transcription level of c-Myc, thereby inducing the quiescence of stem cells (Cell. 2006;126:597-609.). It is possible that TGF-beta signaling pathway is associated with Blimp1, leading to maintain the stemness of sebaceous gland cells.
However, I failed to demonstrate the heterogeneity of Blimp1 expression in the xenograft/ organoid formation as well as in three-dimensional (3D) culture of SZ95 cells, one of the immortalized sebaceous gland cells. Instead, there was the heterogeneity in the expression of Wnt/beta-catenin signal activity only after 3D culture, but not in 2D culture (Biochem Biophys Res Commun. 2013 Sep 6;438(4):640-6.).

Competing interests

No Competing Interests Exist.

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