Open Access Highly Accessed Research article

Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma

Naomi Walsh1, Annemarie Larkin1*, Susan Kennedy2, Lisa Connolly1, Jo Ballot2, Wei Ooi2, Giuseppe Gullo2, John Crown12, Martin Clynes1 and Lorraine O'Driscoll13

Author Affiliations

1 National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland

2 St Vincent's University Hospital, Dublin 4, Ireland

3 Current address - School of Pharmacy & Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland

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BMC Urology 2009, 9:6  doi:10.1186/1471-2490-9-6

Published: 24 June 2009

Abstract

Background

Renal cell carcinoma patients respond poorly to conventional chemotherapy, this unresponsiveness may be attributable to multidrug resistance (MDR). The mechanisms of MDR in renal cancer are not fully understood and the specific contribution of ABC transporter proteins which have been implicated in the chemoresistance of various cancers has not been fully defined in this disease.

Methods

In this retrospective study the expression of two of these transporter efflux pumps, namely MDR-1 P-gp (ABCB1) and MRP-1 (ABCC1) were studied by immunohistochemistry in archival material from 95 renal cell carcinoma patients.

Results

In the first study investigating MDR-1 P-gp and MRP-1 protein expression patterns in renal cell carcinoma patients, high levels of expression of both efflux pumps are observed with 100% of tumours studied showing MDR-1 P-gp and MRP-1 positivity.

Conclusion

Although these findings do not prove a causal role, the high frequency of tumours expressing these efflux pumps suggests that they may be important contributors to the chemoresistance of this tumour type.