Table 4 |
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|
Odds ratios (95% confidence intervals) for bladder cancer among regular users of NSAIDs, with adjustment for other drugs – stratified by tumor invasion, tumor grade and TP53 IHC intensity. |
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|
Drug usea |
Invasion |
Noninvasive |
TP53 IHC Intensity |
|||
|
Noninvasive |
Invasive |
Low grade |
High grade |
<3 |
3+ |
|
|
OR (95%CI)b |
OR (95%CI)b |
OR (95%CI)b |
OR (95%CI)b |
OR (95%CI)b |
OR (95%CI)b |
|
|
|
||||||
|
Phenacetin |
2.4 (1.3–4.5) |
2.2 (0.9–5.1) |
2.2 (1.1–4.2) |
4.3 (1.0–17.9) |
2.0 (1.1–3.8) |
2.7 (1.2–6.5) |
|
Paracetamol |
0.6 (0.3–1.1) |
1.1 (0.5–2.2) |
0.5 (0.2–0.9) |
2.0 (0.6–6.4) |
0.4 (0.2–0.8) |
1.7 (0.8–3.5) |
|
All NSAIDs |
0.7 (0.4–1.0) |
0.5 (0.3–1.0) |
0.7 (0.5–1.1) |
0.4 (0.1–1.4) |
0.8 (0.5–1.2) |
0.5 (0.3–0.9) |
|
Aspirin |
0.6 (0.3–1.0) |
0.4 (0.2–0.9) |
0.6 (0.4–1.0) |
0.5 (0.1–1.8) |
0.7 (0.4–1.1) |
0.4 (0.2–0.9) |
|
Ibuprofen |
0.7 (0.4–1.3) |
0.7 (0.3–1.6) |
0.8 (0.4–1.4) |
0.3 (0.0–2.3) |
0.9 (0.5–1.6) |
0.6 (0.2–1.4) |
|
|
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|
a Restricted to the 327 subjects having pathologic examination of tumor material and confirmation of diagnosis. b Referent category is never use of NSAID medications. Model adjusted by age, sex, number of cigarettes smoked per day, and use of other NSAIDs and analgesics. |
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|
Fortuny et al. BMC Urology 2007 7:13 doi:10.1186/1471-2490-7-13 |
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