Table 1

Radiation sensitization targets
Proteins/genes Site of the cell Cellular process
Rad17-RFC complex Nucleus DNA damage sensor
9-1-1 complex Nucleus DNA damage sensor
MRN complex Nucleus DNA damage sensor
ATM (ataxia-telangiectasia mutated) Nucleus DNA repair
ATR (ataxia- and Rad3-related) Nucleus DNA repair
P53 Nucleus DNA repair
MDM2 Nucleus Negative regulator of p53
Chk2 Nucleus Cell cycle
p21 Nucleus Cell cycle
Cyclin E-CDK2 complex Nucleus Cell cycle
pRB Nucleus Cell cycle
E2F Nucleus Cell cycle
Cdc25A Nucleus Cell cycle
CDK2 Nucleus Cell cycle
CDK4 Nucleus Cell cycle
Cyclin B-CDK1 complex Nucleus Cell cycle
CAK (CDK activating kinase) Nucleus Cell cycle
Histone H2AX Nucleus Nucleosome formation
53BP1 Nucleus P53 phosphorylation
Ki-67 Nucleus Cellular proliferation
Bcl-2 Mitochondria Apoptosis
Bax Mitochondria Apoptosis
PTEN Cytoplasm Apoptosis and proliferation
Akt Cytoplasm, nucleus Apoptosis and proliferation
PAR-4 Cytoplasm, nucleus Apoptosis
Caspase-1 Cytoplasm Apoptosis
Ras Cytoplasm, nucleus Cell growth, differentiation, survival
Cox-2 Cytoplasm, nucleus Cell growth, differentiation, survival

Palacios et al.

Palacios et al. BMC Urology 2013 13:4   doi:10.1186/1471-2490-13-4

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