Open Access Research article

Genetic variation in SPAG16 regions encoding the WD40 repeats is not associated with reduced sperm motility and axonemal defects in a population of infertile males

David R Nagarkatti-Gude12, Giulia Collodel3, Lori D Hill14, Elena Moretti3, Michela Geminiani3, Zhibing Zhang12 and Jerome F Strauss125*

Author Affiliations

1 Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, 23298, VA, USA

2 Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, 23298, VA, USA

3 Department of Biomedical Sciences, Applied Biology Section; Interdepartmental Centre for Research and Therapy of Male Infertility, University of Siena, Policlinico Le Scotte, Siena, 53100, Italy

4 Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, USA

5 MCV Campus, Sanger Hall, 1st Floor, Room 1-071, 1101 East Marshall Street, PO Box 980565, Richmond, 23298, VA, USA

For all author emails, please log on.

BMC Urology 2012, 12:27  doi:10.1186/1471-2490-12-27

Published: 10 September 2012

Additional files

Additional file 1:

Table S1. Minor allele frequencies of all SNPs in the tested SPAG16 region. Expected minor allele frequencies refer to HapMap CEU European population [26] where available. Unknown = no data available for suitable reference population; * = Pilot 1 HapMap CEU panel, 60 individuals.

Format: PDF Size: 6KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 2:

Table S2. Tests for association between all SNPs in sample population and sperm phenotype. Association tests for each SNP found in the sample population and studied indicators of sperm structure and function. * = data assessed using arcsine of the square root of the phenotype; ^ = data assessed using log transformation of the phenotype; c = Bonferroni correction results in p > 0.1.

Format: PDF Size: 27KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data