This article is part of the supplement: Selected articles from the XXV National Congress of the Italian Society of Geriatric Surgery

Open Access Research article

Use of statins in lower extremity artery disease: a review

Giuseppe Gargiulo1, Giuseppe Giugliano1, Linda Brevetti1, Anna Sannino1, Gabriele Giacomo Schiattarella1, Federica Serino1, Andreina Carbone1, Fernando Scudiero1, Marco Ferrone1, Roberto Corrado1, Raffaele Izzo1, Lorenzo Chiariotti2, Cinzia Perrino1, Bruno Amato3, Bruno Trimarco1 and Giovanni Esposito1*

Author Affiliations

1 Department of Clinical Medicine and Cardiovascular and Immunology Sciences, Federico II University, via Pansini 5, 80131, Naples, Italy

2 Department of Biology and Cellular and Molecular Pathology, Federico II University, via Pansini 5, 80131, Naples, Italy

3 Department of General, Geriatric, Oncologic Surgery and Advanced Technologies, Federico II University, via Pansini 5, 80131, Naples, Italy

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BMC Surgery 2012, 12(Suppl 1):S15  doi:10.1186/1471-2482-12-S1-S15

Published: 15 November 2012



Lower extremity artery disease (LE-PAD) is one of the most common manifestations of atherosclerosis, particularly in elderly patients, and it is related to a high cardiovascular risk.


It is well established that statin therapy is characterized by crucial benefits on cardiovascular system by limiting atherosclerotic progression and reducing cardiovascular events and mortality. A growing body of evidence support efficacy of statins in LE-PAD due to the ability of both reducing cardiovascular risk and improving walking distance and, hence, quality of life. Consequently, statin therapy should be considered in all LE-PAD patients and new LDL-cholesterol targets should be reached.


Our opinion is that statin therapy remains still underutilized or with inadequate dosage, so therapy of LE-PAD patients should be improved to obtain all the demonstrated benefits of statins.