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Study protocol
SUBMIT: Systemic therapy with or without up front surgery of the primary tumor in breast cancer patients with distant metastases at initial presentation
Jetske Ruiterkamp, Adri C Voogd, Vivianne CG Tjan-Heijnen, Koop Bosscha, Yvette M van der Linden, Emiel JT Rutgers, Epie Boven, Maurice JC van der Sangen, Miranda F Ernst* and In collaboration with Dutch Breast Cancer Trialists' Group (BOOG)