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Clinicopathological analysis of recurrence patterns and prognostic factors for survival after hepatectomy for colorectal liver metastasis

Michihiro Hayashi1*, Yoshihiro Inoue1, Koji Komeda1, Tetsunosuke Shimizu1, Mitsuhiro Asakuma1, Fumitoshi Hirokawa1, Yoshiharu Miyamoto1, Junji Okuda1, Atsushi Takeshita2, Yuro Shibayama2 and Nobuhiko Tanigawa1

Author Affiliations

1 Department of General and Gastroenterological Surgery, Osaka Medical College Hospital 2-7 Daigaku-machi, Takatsuki City, Osaka 5698686, Japan

2 Department of Pathology, Osaka Medical College Hospital 2-7 Daigaku-machi, Takatsuki City, Osaka 5698686, Japan

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BMC Surgery 2010, 10:27  doi:10.1186/1471-2482-10-27

Published: 27 September 2010



Hepatectomy is recommended as the most effective therapy for liver metastasis from colorectal cancer (CRCLM). It is crucial to elucidate the prognostic clinicopathological factors.


Eighty-three patients undergoing initial hepatectomy for CRCLM were retrospectively analyzed with respect to characteristics of primary colorectal and metastatic hepatic tumors, operation details and prognosis.


The overall 5-year survival rate after initial hepatectomy for CRCLM was 57.5%, and the median survival time was 25 months. Univariate analysis clarified that the significant prognostic factors for poor survival were depth of primary colorectal cancer (≥ serosal invasion), hepatic resection margin (< 5 mm), presence of portal vein invasion of CRCLM, and the presence of intra- and extrahepatic recurrence. Multivariate analysis indicated the presence of intra- and extrahepatic recurrence as independent predictive factors for poor prognosis. Risk factors for intrahepatic recurrence were resection margin (< 5 mm) of CRCLM, while no risk factors for extrahepatic recurrence were noted. In the subgroup with synchronous CRCLM, the combination of surgery and adjuvant chemotherapy controlled intrahepatic recurrence and improved the prognosis significantly.


Optimal surgical strategies in conjunction with effective chemotherapeutic regimens need to be established in patients with risk factors for recurrence and poor outcomes as listed above.