Table 3

Recommendations taking into account the balance of benefit (pain reduction and function improvement) and harm (adverse event)

Product

Grade of recommendation

Quality evidence

Balance benefit to harm


Avocado/soybean unsaponifiables

Strong

Moderate

Avocado/soybean unsaponifiables advantageous

Chondroitin sulfate

Strong

Moderate

Chondroitin sulfate advantageous

Diacereine

Strong

Moderate

Diacereine advantageous

Glucosamine sulfate

Strong

Moderate

Glucosamine sulfate advantageous

Hyaluronic acid

Strong

Moderate

Hyaluronic acid advantageous

Oral calcitonin

Weak

Low

Calcitonin not advantageous

Risedronate

Strong

High

Risedronate not advantageous

Strontium ranelate

Weak

Very low

Strontium ranelate advantageous


Bruyère et al. BMC Musculoskeletal Disorders 2008 9:165   doi:10.1186/1471-2474-9-165

Open Data