Table 1

Control Data Throughout the Course of the Study
Parameter
 OVX T1
 Sham T1
 OVX T1
 OVX T5
 Sham T5
 OVX T5
 OVX T13
 Sham T13
 OVX T13

(n = 9)
 (n = 9)
 vs. Sham T1
 (n = 9)
 (n = 9)
 vs. Sham T5
 (n = 9)
 (n = 9)
 vs. Sham T13

Assessment at 1 Week
 p-value
 Assessment at 5 Weeks
 p-value
 Assessment at 13 Weeks
 p-value
Full BV/TV (%)
 69 ± 3
 72 ± 2
 <0.001
 67 ± 2
 75 ± 3
 <0.001
 67 ± 3
 75 ± 3
 <0.001
Tb.BV/TV (%)
 15 ± 6
 26 ± 5
 <0.001
 5 ± 3
 28 ± 12
 <0.001
 5 ± 4
 34 ± 11
 <0.001
Tb.Th (mm)
 0.08 ± 0.01
 0.1 ± 0.01
 <0.001
 0.06 ± 0.01
 0.10 ± 0.01
 <0.001
 0.06 ± 0.01
 0.11 ± 0.02
 <0.001
Tb.Sp (mm)
 0.28 ± 0.50
 0.28 ± 0.05
 NS
 0.66 ± 0.16
 0.28 ± 0.12
 <0.001
 0.62 ± 0.21
 0.24 ± 0.61
 <0.001
Tb.N (1/mm)
 3.7 ± 0.6
 3.7 ± 0.5
 NS
 1.6 ± 0.5
 3.9 ± 0.9
 <0.001
 1.9 ± 0.9
 4.2 ± 0.7
 <0.001
Tb.Conn (1/mm3)
 17 ± 11
 28 ± 7
 NS
 4 ± 3
 24 ± 8
 <0.001
 5 ± 4
 27 ± 9
 <0.001
Ct.TV (mm3)
 1.9 ± 0.2
 1.9 ± 0.3
 NS
 1.9 ± 0.2
 1.9 ± 0.1
 NS
 1.9 ± 0.1
 2.0 ± 0.2
 NS
Ct.MV/TV (%)
 56 ± 3
 52 ± 3
 0.02
 50 ± 3
 51 ± 3
 NS
 49 ± 3
 47 ± 4
 NS
Ct.Th (mm)
 0.22 ± 0.02
 0.25 ± 0.03
 NS
 0.26 ± 0.02
 0.26 ± 0.02
 NS
 0.26 ± 0.02
 0.29 ± 0.04
 NS

Plus-minus values represent the mean ± standard deviation. Statistical analysis was performed by ANOVA with post-hoc multiple comparisons using the Fisher least significant difference (LSD) method. T1 = sacrificed after 1 week; T5 = sacrificed after 5 weeks; T13 = sacrificed after 13 weeks. Vehicle-treated animals. NS = not significant; Full BV/TV: Whole Bone Volume Density; Tb. BV/TV: Trabecular Bone Volume Density; Tb.Th: Trabecular Thickness; Tb.Sp: Trabecular Spacing; Tb.N: Trabecular Number; Ct.TV: Cortical Total Volume; Ct.MV/TV: Cortical Marrow Volume Density; Ct.Th: Cortical Thickness.

von Stechow et al. BMC Musculoskeletal Disorders 2003 4:8   doi:10.1186/1471-2474-4-8