Table 3

Effect of 1,25-(OH)2D3 on osteoclastic parameters in fourth lumbar vertebral trabecular bone

Exp

Dose

Time

N.Oc/T.Ar (#/mm2)

N.Oc/B.Pm (#/mm)

N.ApOc/T.Ar (#/mm2)


Vehicle

1,25-(OH)2D3

Vehicle

1,25-(OH)2D3

Vehicle

1,25-(OH)2D3


2

3 × 10 μg/kg

4 d

33.9 ± 5.0

66.4 ± 5.5*

3.9 ± 0.7

7.7 ± 1.0*

0

4.6 ± 1.3*

3

3 × 2 μg/kg

4 d

31.0 ± 1.7

56.3 ± 3.3*

3.5 ± 0.4

6.9 ± 0.4*

0.5 ± 0.3

3.1 ± 0.4*

6 d

35.0 ± 4.2

16.7 ± 0.6*

4.1 ± 0.5

3.3 ± 0.1*

0.7 ± 0.2

3.5 ± 0.3*

9 d

30.6 ± 7.3

33.9 ± 4.7

3.8 ± 0.8

3.9 ± 0.7

0.7 ± 0.2

0.7 ± 0.2

13 d

26.7 ± 2.4

46.9 ± 4.8*

2.9 ± 0.4

5.1 ± 0.3*

0.7 ± 0.2

1.2 ± 0.4

17 d

30.3 ± 5.0

44.0 ± 4.5

3.5 ± 0.3

4.6 ± 0.6

0.5 ± 0.2

1.0 ± 0.3

4

3 × 0.2 μg/kg

4 d

28.8 ± 1.9

27.3 ± 1.9

3.0 ± 0.2

2.7 ± 0.2

0.2 ± 0.2

0

6 d

28.2 ± 1.5

27.1 ± 2.6

3.0 ± 0.1

3.0 ± 0.2

0.2 ± 0.2

0

8 d

26.9 ± 2.8

29.2 ± 2.2

2.9 ± 0.2

3.2 ± 0.4

0

0.4 ± 0.2

10 d

29.4 ± 2.4

31.7 ± 2.3

3.7 ± 0.1

3.1 ± 0.3

0.2 ± 0.2

0.4 ± 0.2

12 d

31.5 ± 2.7

32.5 ± 3.3

3.3 ± 0.3

3.6 ± 0.3

0.2 ± 0.2

0.2 ± 0.2

14 d

30.6 ± 3.2

29.8 ± 2.7

3.5 ± 0.3

3.5 ± 0.3

0

0.2 ± 0.2


All values are mean ± SE, *: P < 0.05

Miao and Scutt BMC Musculoskeletal Disorders 2002 3:16   doi:10.1186/1471-2474-3-16

Open Data