Table 2

Effect of 1,25-(OH)2D3 on Osteoclastic parameters in rat tibial trabecular bone

Exp

Dose

Time

N.Oc/T.Ar (#/mm2)

N.Oc/B.Pm (#/mm)

N.ApOc/T.Ar (#/mm2)


Vehicle

1,25-(OH)2D3

Vehicle

1,25-(OH)2D3

Vehicle

1,25-(OH)2D3


1

1 × 10 μg/kg

1 d

63.1 ± 2.0

61.7 ± 2.9

6.0 ± 0.5

6.4 ± 0.8

0.7 ± 0.3

1.0 ± 0.6

2

3 × 10 μg/kg

4 d

76.7 ± 2.4

65.7 ± 3.8

7.5 ± 0.1

6.3 ± 0.3

1.0 ± 0.6

11.7 ± 0.9*

3

3 × 2 μg/kg

4 d

75.0 ± 6.3

111.0 ± 2.0*

7.0 ± 0.3

9.7 ± 5.3*

0.3 ± 0.3

10.3 ± 0.7*

6 d

85.1 ± 9.5

41.3 ± 12.9*

8.4 ± 0.5

3.2 ± 1.1*

1.0 ± 0.6

5.0 ± 0.6*

9 d

91.9 ± 10.

98.4 ± 9.8

8.8 ± 0.7

8.8 ± 0.6

0.7 ± 0.3

0.7 ± 0.3

13 d

9

81.1 ± 4.5

8.9 ± 1.2

6.7 ± 0.7

0.7 ± 0.3

0.3 ± 0.3

17 d

71.0 ± 5.3

73.9 ± 2.6

6.5 ± 0.2

6.5 ± 0.4

0.7 ± 0.3

1.0 ± 0.6

73.5 ± 2.2

4

3 × 0.2 μg/kg

4 d

39.2 ± 4.9

33.4 ± 3.0

3.5 ± 0.3

3.9 ± 0.2

0.4 ± 0.2

0.6 ± 0.2

6 d

32.9 ± 2.4

45.1 ± 4.1*

3.8 ± 0.3

5.1 ± 0.7*

0.6 ± 0.2

1.0 ± 0.3

8 d

37.6 ± 5.6

23.4 ± 2.1*

5.2 ± 0.7

3.1 ± 0.2*

0.4 ± 0.2

1.6 ± 0.2*

10 d

35.5 ± 3.4

40.9 ± 3.5

5.2 ± 0.5

4.6 ± 0.6

0.4 ± 0.2

0.8 ± 0.4

12 d

36.9 ± 5.0

39.0 ± 7.9

4.6 ± 0.3

4.5 ± 0.4

0.4 ± 0.2

0.6 ± 0.2

14 d

41.1 ± 3.9

37.5 ± 1.3

5.7 ± 0.5

4.9 ± 0.4

0.2 ± 0.2

0.4 ± 0.2


All values are mean ± SE, *: P < 0.05

Miao and Scutt BMC Musculoskeletal Disorders 2002 3:16   doi:10.1186/1471-2474-3-16

Open Data