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Synaptosomal-associated protein 25 (Snap-25) gene Polymorphism frequency in fibromyalgia syndrome and relationship with clinical symptoms

Ayse Balkarli1*, Cem Sengül2, Emre Tepeli3, Huseyin Balkarli4 and Veli Cobankara1

Author Affiliations

1 Department of Internal Medicine, Division of Rheumatology, Pamukkale University Hospital, Kınıklı, 20070 Denizli, Turkey

2 Department of Psychiatry, Pamukkale University Hospital, Kınıklı, 20070 Denizli, Turkey

3 Department of Medical Biology, Pamukkale University Hospital, Kınıklı, 20070 Denizli, Turkey

4 Department of Orthopedics and Traumatology, Akdeniz University Hospital, Dumlupınar Avenue, 07070 Antalya, Turkey

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BMC Musculoskeletal Disorders 2014, 15:191  doi:10.1186/1471-2474-15-191

Published: 31 May 2014



SNAP-25 protein is contributory to plasma membrane and synaptic vesicle fusions that are critical points in neurotransmission. SNAP-25 gene is associated with behavioral symptoms, personality and psychological disorders. In addition, SNAP-25 protein can be related to different neurotransmitter functions due to its association with vesicle membrane transition and fusion. This is important because neurologic, cognitive, and psychologic disorders in fibromyalgia syndrome (FMS) can be related to this function. This relationship may be enlightening for etiopathogenesis of FMS and treatment approaches. We aimed to study a SNAP-25 gene polymorphism, which is related to many psychiatric diseases, and FMS association in this prospective study.


We included 71 patients who were diagnosed according to new criteria and 57 matched healthy women in this study. Both groups were evaluated regarding age, height, weight, BMI, education level, marital and occupational status. A new diagnosis of FMS was made from criteria scoring, SF-36, Beck depression scale, and VAS that were applied to the patient group. SNAP-25 gene polymorphism and disease activity score correlations were compared.


Mean age was 38±5,196 and 38.12±4.939 in patient and control groups, respectively (p=0.542). No significant difference was found between groups regarding age, height, weight, BMI, education level, marital or occupational status (p > 0.05). Ddel T/C genotype was significantly higher in the patient group (p = 0.009). MnlI gene polymorphism did not show a correlation with any score whereas a significant correlation was found between Ddel T/C genotype and Beck depression scale and VAS score (p < 0.05).


FMS etiopathogenesis is not clearly known. Numerous neurologic, cognitive and psychological disorders were found during studies looking at cause. Our study showed increased SNAP-25 Ddel T/C genotype in FMS patients compared to the control group, which is related to behavioral symptoms, personality and psychological disorders in FMS patients.

Fibromyalgia; Synaptosomal-associated protein 25 gene polymorphism