Table 2

Studies comparing non-structural autologous bone grafts with substitutes in hindfoot arthrodeses and osteotomies
Ref. Methodology Results Quality
Cancellous allografts versus cancellous autologous grafts in hindfoot ADs
McGarvey et al.[58] Retrospective comparative chart review (1990–1992) Rate of union Selection: ***
Allografts: 21/24 (88%) Comparability:
24 acellular allograft chips vs 17 cancellous autologous grafts in 37 subtalar, double and triple ADs. FU: Minimum 18 months Autologous grafts: 16/17 (94%) Outcome:*
P=?
Time-to- union
Triple/Double/Subtalar AD
Allografts: 4.0/4.0/4.1 months
Autologous grafts 3.0/3.2/3.6 months
P= n. s
Easley et al.[4] Subgroup comparison in a retrospective chart review (1988–1995) Rate of union Selection: **
Allografts: 14/17 (82%) Comparability:
17 cancellous allograft vs. 94 cancellous autologous grafts in subtalar ADs. Mean FU 51 months(range: 24–130 months) Autologous grafts: 80/94 (85%) Outcome:*
P= n. s.
Time –to- union
Allografts: 13 weeks
(10–24 weeks)
Autologous grafts: 11weeks (8–20 weeks)
P= n. s
DBM versus cancellous autologous grafts in hindfoot ADs
Michelson et al.[57] Prospective comparative study (1990–1993) Rate of union Selection: ***
37 DBM vs.18 cancellous autologous grafts in 11 subtalar AD’s, and 44 triple AD’s FU: Until complete healing DBM: 36/37 (97%) Comparability:
Autologous grafts: 16/18 (89%) Outcome:***
P= n. s.
Time –to-union
DBM: 3.0 – 3.4 months
Autologous grafts 2.7-3.7 months
P=n. s.
No graft versus cancellous autologous grafts in hindfoot ADs
Easley et al. [4] Subgroup comparison in a retrospective chart review (1988–1995) Rate of union Selection: **
No graft: 34/39 (87%) Comparability:
39 “no graft” vs 94 cancellous autologous grafts in isolated subtalar ADs. Mean FU 54 months (range: 24–130 months) Autologous grafts: 80/94 (85%) Outcome:*
P= n. s.
Time-to-union
No graft: 11w (8–24)
Autologous grafts: 11weeks (8–20 weeks)
P= n. s
Synthetic bone grafts versus cancellous autologous grafts in hindfoot ADs
DiGiovanni et al. [56] Randomized controlled trial (2006/7) Rate of X ray based union at 6-12-36 weeks: No concealed allocation Blinded outcome assessment 80-93% follow-up Underpowered study
14 PDGF augmented ß-TCP (Augment ®) vs 6 cancellous autologous grafts in 20 adult subtalar, triple, ankle ADs. FU:6, 12 and 36 weeks
PDGF/ß-TCP:
0/11(0%)-5/12(42%)-10/13
Autologous grafts:
0/4 (0%)-1/3 (33%)-3/5 (60%)
P= ?
Rate of CT based union at 6–12 weeks
PDGF/ß-TCP:
5/13 (38%)-9/13% (69%)
Autologous grafts:
2/5 (40%)- 3/5 (60%)
P= ?

Abbreviations: OTs= osteotomies, ADs= arthrodeses, FU= follow-up, n.s.= not significant.

Müller et al.

Müller et al. BMC Musculoskeletal Disorders 2013 14:59   doi:10.1186/1471-2474-14-59

Open Data