Table 3

Osteogenic genes at least 3-fold upregulated or downregulated in osteoporotic bone tissue
Gen symbol ID gen(GeneBannk) Function Fold change
BGLAP NM_199173 Skeletal Development - 3.39
BMP5 NM_ 001718 Skeletal Development - 3.87
BMP6 NM_021073 Skeletal Development - 3.30
CDH11 NM_001797 Bone Mineral Metabolism - 3.30
COL14A1 NM_021110 Bone Mineral Metabolism - 9.54
COMP NM_000095 Bone Mineral Metabolism - 4.63
EGFR NM_005228 Cell growth and differentiation −5.28
FGF1 NM_000800 Cell growth and differentiation 3.3
FGFR1 NM_015850 Cell growth and differentiation - 5.95
FGFR2 NM_000141 Cell growth and differentiation - 5.63
IGF1R NM_000875 Cell growth and differentiation - 8.96
VEGFA NM_003376 Cell growth and differentiation 3.00
TGFBR1 NM_004612 Cell Proliferation - 6.31
TGFRB2 NM_003242 Cell Proliferation - 7.04
VCAM1 NM_001078 Cell adhesion Molecules - 8.36
MMP2 NM_004530 Extracellular matrix Proteases - 4.36
MMP8 NM_002424 Extracellular matrix Proteases 5.06
NFKB1 NM_003998 Transcription Factors and regulators - 3.06
SMAD2 NM_005901 Transcription Factors and regulators - 3.42
SMAD3 NM_005902 Transcription Factors and regulators - 5.25
SOX9 NM_000346 Transcription Factors and regulators - 5.00
RUNX-2 NM_004348 Transcription Factors and regulators - 2.94
TNF NM_000594 Transcription Factors and regulators - 9.18

Giner et al.

Giner et al. BMC Musculoskeletal Disorders 2013 14:41   doi:10.1186/1471-2474-14-41

Open Data