Expression levels of Sema3A mRNA correlate with histological features in RA synovial tissues. Correlations between Sema3A mRNA expression levels and histological parameters of RA synovial tissues were assessed. Histological parameters were scored separately on a scale of 0–10 according to Rooney’s inflammation scoring system. Correlation of Sema3A mRNA levels and synoviocyte hyperplasia (A); Sema3A mRNA levels and fibrosis (B); Sema3A mRNA levels and proliferating blood vessels (C); Sema3A mRNA levels and perivascular infiltrates of lymphocytes (D); Sema3A mRNA levels and focal aggregates of lymphocytes (E); and Sema3A mRNA levels and diffuse infiltrates of lymphocytes (F). Correlations were examined using Spearman’s rank correlation coefficient.
Takagawa et al. BMC Musculoskeletal Disorders 2013 14:40 doi:10.1186/1471-2474-14-40