Table 1

Age, histological and biochemical findings in patient groups
Reference (n = 20) OA (n = 16) P value
Age (years) 83 (77–85.5) 66.5 (61–75.5) ≤0.001
Mankin grade 2 (1–2) 4 (3.5-5) ≤0.001
Immunostaining score 0.5 (0.5-0.5) 2 (2–3) ≤0.001
ECP 0.45 (0.38-0.63) 1.04 ( 0.84-1.56) ≤0.001
% Hydration 68.1 (64–70.4) 73.6 (70.8-77.9) ≤0.001
GAG
Wet 39.8 (34–45.6) 38.6 (34–45.2) 0.644
Dry 128.8 (119.6-135) 152.8 (129.4-165) 0.012
Total hydroxyproline
Wet 25.3 (23.1-27.5) 22.4 (18–27.3) 0.083
Dry 79.6(72.2-87) 84.6 (76.4-95.7) 0.233

Reported values are medians (25–75 percentiles). Values of GAG and total hydroxyproline (i.e. total collagen) are expressed as micrograms per milligram wet and dry weight of cartilage tissue. ECP stands for % extractable collagen pool and is expressed as a percentage of the total amount of collagen.

Hosseininia et al.

Hosseininia et al. BMC Musculoskeletal Disorders 2013 14:18   doi:10.1186/1471-2474-14-18

Open Data