Table 2

In vitro results of hMSC cultured on HDM_derm and CTR for 7 and 14 days
HDM_derm CTR Two-way ANOVA
7 days 14 days 7 days 14 days
CPII (pg/mg) 82.2 ± 1.5 136.8 ± 3.0° 90.9 ± 4.1 140.9 ± 2.6° F=4.86, p < 0.05
Aggrecan (ng/mg) 191.7 ± 6.1*** 265.7 ± 7.4***, °°° 129.7 ± 3.5 184.0 ± 5.0°°° F=24.02, p < 0.0005
TGF-β1 (pg/mg) 926.9 ± 4.5*** 894.1 ± 18.9*** 644.2 ± 23.1 324.1 ± 75.6°°° F=37.3, p < 0.0005
IL-1β (pg/mg) 0.5 ± 0.0 0.5 ± 0.1 0.4 ± 0.0 0.6 ± 0.0 NS
MMP3 (ng/mg) 0.01 ± 0.01 0.18 ± 0.03 Not detected Not detected NS

Bonferroni t test (Mean ± SD, n = 8 replicates):

- between HDM_derm and CTR within each experimental time: ***, p<0.0005.

- between experimental times within each tested membrane: °, p<0.05; °°°, p<0.0005.

Giavaresi et al.

Giavaresi et al. BMC Musculoskeletal Disorders 2013 14:12   doi:10.1186/1471-2474-14-12

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